Response: An IriSys client was having problems formulating a compound for oral administration that was characterized by low solubility in both water and oil, and degraded rapidly in acid. Our solution involved developing a semi-solid matrix that withstood the heating necessary for it to be liquified for capsule filling. The capsules were enteric-coated to protect the active ingredient from degradation in acid. Our client had a very positive outcome, with preclinical and human studies demonstrating significant improvement in bioavailability.
Please follow and like us: