Difficult to Develop Products

IRISYS creates new formulations that are tailored to a drug’s physical and chemical characteristics; each formulation is unique to the compound. We provide world-class dosage form development services, both classical and proprietary.

Poorly soluble compounds

IRISYS is a pioneer in the development of liquid-filled hard gelatin and HPMC (hydroxypropyl methylcellulose) capsule formulation technologies. We create solutions for issues related to the unique physical and chemical characteristics of a drug compound. These characteristics may include:

  • Insolubility
  • Poor solubility
  • Poor bioavailability
  • Lack of content uniformity
  • Hygroscopicity

Wide range of dosage forms

IRISYS’ team develops formulations for dosage forms that are appropriate for small molecules, peptides and proteins.

Applications:

  • Small organic molecules
  • Peptides and biologics
  • Proteins
  • Synthetic polymers
  • Inorganic compounds
  • Cytotoxic and potent compounds

Dosage forms:

  • Tablets
  • Capsules, powder-filled
  • Capsules, liquid-filled
  • Oral solutions and suspensions
  • Topical products
  • Injectables
  • Controlled release products
  • Sustained release products
  • Pellets
  • Microspheres

Oral:

  • Moving from multiple daily doses to once daily
  • Controlled release of highly water soluble drugs
  • Immediate release of highly lipophilic drugs

Parenteral:

  • Increased circulating half-life, optimized bio-distribution
  • Improved safety and efficacy
  • Decreased immune recognition
  • Targeted delivery
  • Discriminative release (location and environment)
  • Pharmacodynamically optimized formulations
  • Long-acting formulations
  • Lyophilized products

Topical:

  • Increased bioavailability
  • Enhanced stability
  • Optimized viscosity
  • Optimized polymer network for high electrolyte content

For help with your Difficult to Develop Product, fill out the contact form below: